Description
A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C5H4N2O4, C5H4N2O4 | 0 | 156.09630 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | OC(=O)c1cc(=O)[nH]c(=O)[nH]1 | InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) | PXQPEWDEAKTCGB-UHFFFAOYSA-N |
|
Citations
- Asai, M, et al. 2000. Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic diseases. Pediatrics International : Official Journal of the Japan Pediatric Society. 42(5).
- D'Apolito, O, et al. 2011. Reference intervals for orotic acid in urine, plasma and dried blood spot using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 883-884.
- Fryčák, P, et al. 2012. Secondary processes in atmospheric pressure chemical ionization-ion trap mass spectrometry: a case study of orotic acid. Journal of Mass Spectrometry : JMS. 47(6).
- Gargallo, J, et al. 1981. Effect of casein and starch infusion in the large intestine on nitrogen metabolism of growing swine. The Journal of Nutrition. 111(8).
- Gerhardt, V, et al. 2012. Conformational studies of hydantoin-5-acetic acid and orotic acid. Acta Crystallographica. Section C, Crystal Structure Communications. 68(Pt 2).
- Jung, EJ, et al. 2012. Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells. The Journal of Toxicological Sciences. 37(4).
- Khajehsharifi, H, et al. 2012. Spectrophotometric simultaneous determination of orotic acid, creatinine and uric acid by orthogonal signal correction-partial least squares in spiked real samples. Drug Testing and Analysis. 5(5).
- Niu, H, et al. 2012. Ion-exclusion chromatography determination of organic acid in uridine 5'-monophosphate fermentation broth. Journal of Chromatographic Science. 50(8).
- Pôrto, LC, et al. 2012. Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid. Life Sciences. 90(13-14).
- Roux, A, et al. 2012. Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Analytical Chemistry. 84(15).